

The list of vulnerability mitigations for those old CPUs is going to be a mile long. They will probably have their performance cut in half or worse. Even a much newer CPU like Zen 1 takes a big performance hit.
You can disable mitigations, but then a malicious website could potentially steal sensitive information on that computer.

Wine has support serial and parallel ports. They work fine. In recent versions of wine you don’t even have to set anything up. Just run
ls -l ~/.wine/dosdevices/com*after running something in wine to see what the com port number is for your device. The ttyACM and ttyUSB ports are USB serial ports. The ttyS ports are hardware serial ports and they will probably show up even if your computer doesn’t have any.