I avoid O365 as much as possible, but when I need to, I do occasionally use it with Crossover and it seems to work. Activation was a little bit janky, but did work.
Crossover is a paid version of WINE, and the other apps I’ve seen mentioned run Windows in a VM and forward the apps through RDP. There are advantages to both approaches, but I prefer the efficiency of Crossover.



Yeah it used to be broken for me too, I think only recently did it actually let me activate it. My university also uses Duo 2FA, and I activated it fine. But sometimes it doesn’t activate on the first try, you have to reopen office a few times.
Also it seems to only let you activate it, you can’t actually sign in with your account for online features yet.