I’ll preface my comment with I understand my setup is no where similar to yours, but I’ll share my setup to hopefully give you an idea as to what you can do.
My desktop is running Unraid, and I’ve set it up with GPU pass through. This lets me spin up a machine with its own virtual drive with the OS installed. My other main folders (Documents, pictures, etc…) connect via network folders.
Pro: Can try out a bunch of OSs easily, and I don’t really care if I nuke my OS drive.
Con: The GPU passthrough can be very finicky. Admittedly, It was a struggle to get everything setup initially; but I think Unraid is working on streamlining that process.
I’d also recommend looking into setting it up in Proxmox first if you want to try this route. Proxmox is free, and Unraid is paid; so if you just want to play around with the idea, try the free version first.
Hope this helps!
Unfortunately I don’t recall the exact reason why I chose Unraid over Proxmox. It might have been better GPU passthrough support at the time, or better Docker container support?